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Figure 1 Oligomeric A 40 Induces Free Radical Damage to DNA, Lipids, and Protein Which Could be Attenuated Using GGC To confirm that oligomeric A 40 is cytotoxic to astrocytes via induction of oxidative stress, we monitored the effect of oligomeric A 40 on free radical generation

Follow-up work might move to animal models where histological scoring, imaging, and functional tests allow for more complex observations, always with appropriate controls and ethical oversight

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Due to the charge and hydrophilic nature of the molecule, passive diffusion across cell membranes is inefficient (50)

doi: 10.1093/epirev/mxt007