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Mice engineered to overexpress a single-chain variable fragment of E06, an IgM NAb directed against oxidized phospholipids (oxPL), were found to have reduced atherosclerosis and features consistent with greater overall plaque stability, confirming the atheroprotective nature of these B-1 cell-derived antibodies (94)

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The principal role of carnitine is to transport long-chain fatty acids into the mitochondria for energy production via beta-oxidation (46), but it also participates in glucose metabolism, detoxification of acyl moieties (47), and in the preservation of intracellular Coenzyme A (CoA) homeostasis (48)

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