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In summary, they have identified renal ferroptosis as a pathological feature and contributing factor of tubular injury in human and mice lupus nephritis [134]

10.4103/njcp.njcp_349_19 186

Additionally, ROS serve as important second messengers in T cell receptor (TCR) signaling for proliferation and effector function [86]

By stimulating Uncoupling Protein 2 (UCP-2), berberine also helps dissipate excess metabolic energy as heat, further preventing the accumulation of oxidative stress within the mitochondria

This suggests that the cells rely on GPX4 to resist oxidative stress, and this could potentially increase their sensitivity to RSL3, a ferroptosis inducer that targets GPX4