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Hypertrophic adipose tissue is associated with immune cell recruitment, increased basal fatty acid release, pro-inflammatory cytokine release, hypoxia, necrotic-like abnormalities, fibrosis, decreased adiponectin, impaired insulin sensitivity, and insulin-dependent glucose uptake related to a defect in GLUT4 trafficking (Choe et al., 2016)

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When the anabolic threshold of liver in producing organ functional proteins and lipids (like glycogen and cholesterol) is diverted to production of triglycerides, fatty acids and glucose

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