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At its core dementia results from a combination of diminished synaptic connectivity among neurons and neuronal death in the entorhinal cortex, hippocampus and neocortex

Nevertheless, although a specific action of homocysteine seems to occur at low concentrations, experimental trials have been conducted only with homocysteine administration, which would reflect a severe hyperhomocysteinemia rather than a more physiologic moderate elevation of circulating homocysteine, and clinical observations have only come from homocystinuric patients with severe hyperhomocysteinemia

An efficacious treatment for AD has not been forthcoming in part due to the large numbers of potentially important biomarkers, the difficulty in determining their diagnostic reliability and validity, and the multifactorial characteristics of the disease process

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