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ROS can directly activate the NF-kB transcription factor pathway, promoting the synthesis of inflammatory cytokines (85)

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In humans, GLP-1 is not only damaged by DPP-4, but also by neutral endopeptidase 24.11 (NEP 24.11), and the main catalytic sites are Glu 27 Phe 28 and Trp 31 Leu 32