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Pros: Non-prescription, making it more accessible

This pleiotropic profile is part of what makes it difficult to model in humans: the compound does not have a single clean pharmacological target

Importantly, resistant cancer cells often compensate for MAPK inhibition by activating parallel survival pathways such as PI3K/AKT/mTOR, suggesting that dual inhibition of mTOR and MAPK signaling in combination with L-ASNase could be an effective strategy to prevent resistance

Meanwhile, many people who could benefit from the drugs feel embarrassed to ask about themor believe they should be able to lose weight on their own

Eligibility guidelines disqualify a significant number of people