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In the pivotal MAESTRO-NASH of THR agonist Rezdiffra, steatohepatitis resolution was seen in 30% of patients on a 100mg dose, compared to 10% with placebo, after 52 weeks

This design allowed the controlled release of metabolites, such as urea, while preventing the release of genetically modified cells into host tissues, thus mitigating safety concerns

Mammalian erythrocytes do not have cell organelles (32) and are therefore incapable of mitochondrial -oxidation

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