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Last Updated: February 2025

In 90-day tests, whether given through the diet (up to 9375 mg/kg BW/day) or by intramuscular injection (up to 0.5 ml/kg/day) in rabbits, no significant signs of toxicity were observed

In the context of eye health, however, these carotenoids are best known for their role in the AREDS2 study developed by the National Eye Institute a large, multi-year clinical trial designed to identify nutrients that protect vision in older adults