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Across 26,436 total participants, they identified 252 different serious adverse events and calculated the relative risk for each one

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021

[40] report that oral ALA supplementation (1200 mg/12 weeks) resulted in a significant reduction in the serum leptin concentration and a noticeable elevation in the adiponectin-to-leptin ratio in patients with non-alcoholic fatty liver disease

These findings come from smaller imaging cohorts using computed tomography (CT) and magnetic resonance imaging (MRI), though it's important to note that preferential visceral fat reduction is not a licensed indication for these medications in the UK