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The study analyzed 1,364 patients, including mixed-BMI and obese-only groups, uncovering how factors like weight gain, aging, and gender amplify sleep apnea severity

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This, in turn, leads to elevated levels of cyclin-dependent kinase-2 (CDK2), as well as cyclins A and E [25]

Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination