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The study identified two noteworthy metabolomic markers, tyramine and mucic acid, as relevant to the pathogenesis of both psoriasis and its arthritis subtype (123)

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Within the framework of clinical trial design, predictive modeling based on imaging, body fluid biomarkers, genetics, and digital signals can enhance participant selection, identify fast progressors or treatment-responsive subgroups, and enable real-time adaptive modifications to trial parameters

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Moreover, Cadherin-11, an adhesion molecule expressed in fibroblasts, can activate MMP which in turn lead to more collagen deterioration and enhanced elastic fibers in the skin