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Retrieved August 9, 2009

American Heritage defines it as "an inactive substance or preparation used as a control in an experiment or test to determine the effectiveness of a medicinal drug." Merriam-Webster defines it as "an inert or innocuous substance used especially in controlled experiments testing the efficacy of another substance." Is nicotine an inactive, inert, and innocuous substance

However, as the body becomes comfortable with nicotines presence, it becomes difficult for it to quickly restart the whole acetylcholine and dopamine production process

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