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A 2025 systematic review confirmed that probiotic supplementation in T2DM patients leads to a significant elevation in total antioxidant capacity (TAC) and a reduction in malondialdehyde (MDA), a marker of lipid peroxidation (442, 443)

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Cortisol increases the expression of genes for metallothionein and ZIP-14, which accumulate zinc in the liver and adipose tissue, promoting hypozincemia in obese people (157)