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NICE recommends a stepwise approach including dietary modifications (low FODMAP diet), regular physical activity, stress management, and symptom-specific medications such as loperamide for diarrhoea, linaclotide for constipation, and antispasmodics for abdominal pain

Additionally, saxagliptin requires dose reduction when co-prescribed with strong CYP3A4/5 inhibitors such as ketoconazole or clarithromycin (consult the Summary of Product Characteristics for specific guidance)