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There is also considerable variability between individuals

Individual studies should always be interpreted alongside the broader body of evidence

For weight management in people without diabetes , NICE recommends considering semaglutide 2.4 mg (Wegovy) for adults with a BMI 35 kg/m (or lower thresholds for certain ethnic groups) and at least one weight-related comorbidity

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Other genetic profiles show greater resilience to weight regain, offering more flexibility to cycle or discontinue