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GHRP-2 has also been studied for its ability to stimulate GH in patients with mutated GHRH receptors demonstrating that GHSR-1a provides an independent rescue pathway for GH release even when the GHRH axis is compromised (Maheshwari et al., 2002)

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Pegvisomant increases the metabolic rate of food-deprived mice To assess whether the energy-conserving effects of GH can be pharmacologically manipulated, we tested in mice the effects of a clinically available GHR antagonist (pegvisomant)