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Other neurodegenerative disorders including Parkinsons, Huntingtons, and ALS have also been linked with UPS dysfunction, via contributing to the accumulation of toxic aggregates such as -synuclein and huntingtin (Tseng et al., 2008

67 Uric acid regulates the inflammatory response by inhibiting the production of inflammatory mediators, which significantly reduces the formation of free radicals

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This novel method produced medicines that are capable of sustaining therapeutic drug levels for a minimum of 24 h, facilitating once-weekly administration for the majority of these drugs (Holst 2019)