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A key mechanism contributing to cardiometabolic comorbidities like hypertension, dyslipidaemia, T2DM, and obesity is endothelial dysfunction caused by decreased nitric oxide production, increased inflammation and oxidative stress 93,94

Precautions: Individuals with a history of pancreatitis should use saxagliptin with caution, as there have been reports of pancreatitis associated with DPP- 4 inhibitors [10]

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