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GHK-Cu activates fibroblasts, the cells responsible for collagen and elastin synthesis, and triggers extracellular matrix remodeling through metalloproteinase regulation

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However, the activity elicited in the presence of spermatozoa could be distinguished from that generated by somatic cells by virtue of the lack of stimulation observed with NEM [37, 54, 55]

In this instance, abnormal signal within the pons precluded the definitive exclusion of LM