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Disclose pancreatitis, gallbladder disease, severe gastrointestinal symptoms, kidney problems, diabetes treatments, and every medication or supplement during intake

People with severe kidney disease face increased risks because both dehydration-related complications from tirzepatide and bupropion metabolite accumulation from impaired renal clearance create a compounded problem

Treatment typically begins at 0.25 mg once weekly for the first four weeks to improve tolerability, followed by an increase to 0.5 mg

Use an app or marked water bottle to track intake, aiming for at least 64 ounces daily, more if you are active or in a warm climate

Blood sugar levels may also rise, especially in patients with Type 2 diabetes