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Inclisiran is a small interfering RNA (siRNA) that regulates lipid metabolism by inhibiting the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9), while Volanesorsen is an antisense oligonucleotide that regulates lipid metabolism by inhibiting the synthesis of apolipoprotein C-III

72 Ionizing radiation (IR), particularly at high doses (5 Gy), leads to irreversible DNA damage, triggering MSCs to form ectopically pigmented melanocytes (EPMs), which are associated with PHG

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At week 12, there were no significant differences found between the treatment and placebo groups in terms of the total number of UV spots, spot polarization, or measurements of skin tone