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SPMs can decrease levels of pro-inflammatory cytokines, such as IL-1, IL-6, and tumor necrosis factor (TNF)-, through activating their G protein-coupled receptors, thus causing activation of anti-inflammatory transcription factors, such as peroxisome proliferator-activated receptor gamma, and down-regulating intracellular NF-kB signaling pathway (14, 63)

2019) postulated that mechanical stimulation could enhance the regenerative capacity of fibroblast-seeded electrospun membranes

Interestingly, the Nrf2-mediated antioxidant response pathway is highly activated in FH-mutant cells (Ooi et al., 2011)

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