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Indeed, in these studies, APR-246 was administrated for 7 to 28 days, and reduction of tumor volume after 4 days of treatment was minimal at best

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Indeed, glutamate is reported to constrict pial arterioles whereas inhibition of glutamate by an ionotropic receptor antagonist dilates arterioles 18

However, clinical trials investigating intravenous or intranasal GSH showed improvements in PD symptoms but lacked statistical significance over placebo, suggesting a higher dose might be required (203205)

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