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In particular, studies show that menthol attenuates the nACh receptor channel response to nicotine in a dose-dependent, non-competitive manner, and does not interfere with the kinetics of the nACh receptor channel ( FIGURE 2 Menthol alters the addictive properties of nicotine Nicotinic receptors play a key role in addiction by regulating the release of several important neurotransmitters in the brain ( Strong preclinical evidence suggests that 2, 4, 5, 6, and 7 containing nAChRs mediate the reinforcing effects of nicotine (Stoker and Markou, 2013)

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Gottlieb in September warned e-cigarette makers that if they did not fix epidemic levels of teens using their products, he might pull their products altogether

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