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therapy requires trained medical personnel for administration, thus raising costs, patient burden for clinic visits, and risk of discomfort and phlebitis

98 RNF185, an RNF5 paralog, 99 forms an ERAD complex with membralin (MBRL, also known as transmembrane protein 259 (TMEM259)) and transmembrane and ubiquitin-like domain-containing proteins 1 and 2 (TMUB1/2) for substrate recognition

The values were recorded automatically every 30 s

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Here, we review the role of selenium metabolism in cartilage and bone and the significance of maintaining its homeostasis in the context of joint diseases such as KBD and OA