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In conclusion, the regulation of cellular zinc metabolism and the involvement of zinc transporters and MTs play crucial roles in autoimmune diseases
Abbreviations ATC: anaplastic thyroid carcinoma AP: apurinic/apyrimidinic or abasic APE1: apurinic/apyrimidinic endonuclease 1 BER: base excision repair GSH: glutathione TME: tumor micro-environment AP probe-net: AP sites capture reagent WB: western blotting RIT: radioiodine therapy DNS: 2,4-dinitrobenzene sulfonamides MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide RMPI 1640: Roswell park memorial institute 1640 FBS: fetal bovine serum DMSO: dimethyl sulfoxide TBST: tris-buffered saline Tween GSS: glutathione enzyme DSBs: double-strand breaks NSCLC: non-small cell lung cancer References Lorimer C, Cheng L, Chandler R, Garcez K, Gill V, Graham K, et al
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Owing to oxidative damage, multiple covalent bonds in the DNA get modified, including inter and intra-strand crosslinks, strands collapse, crosslinking between proteins and DNA occurs, lesions form in single nucleobase, etc
