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In addition, as migraine prophylactic agents, 400 mg/day of riboflavin was comparable with 500 mg/day of sodium valproate and 100 mg/day of riboflavin was comparable with 80 mg/day of propranolol, with no statistical differences between groups in their prophylactic actions, with a more favorable side effect profile in the riboflavin groups (100)

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A recent study suggested that there may be multiple reasons for remyelination failure in MS patients, according to lesion stage: in a subset of active lesions, a lack of myelin sheath formation was observed despite the presence of mature OLGs, whereas in inactive lesions, OLG loss and a hostile microenvironment were identified as the major causes of remyelination failure (He et al., Subcortical lesions display more extensive remyelination than periventricular and cerebellar lesions, which are often poorly remyelinated (Goldschmidt et al., 2017), as clearly shown by the analysis of leukocortical regions, which embrace both white and gray matter (Chang et al., 2001

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