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Gallbladder disease: Incretin-based therapies have been associated with an increased risk of cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation), as noted in the UK SmPCs for licensed comparators such as semaglutide and tirzepatide

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The oral capsule format is of particular interest in this area, since the swallowed peptide is delivered directly into the gastrointestinal tract, where much of this research activity has historically been localised and where the compounds reported stability in gastric conditions is most relevant