(3) Studies with insufficient methodological detail or irrelevant outcomes (e.g., isolated heat stress without liver injury assessment)
However, elderly patients are more likely to have reduced renal function and hepatic reserve, increasing their susceptibility to adverse effects with prolonged or high-dose use
These findings position USP13 as a key post-translational regulator, linking deubiquitination of BMAL1 to broader rhythms in physiology and highlighting its potential as a molecular target in circadian dysfunction associated with neurodegenerative conditions
[DOI] [PubMed] [Google Scholar] 12.Mawardi H.H., Almazrooa S.A., Dakhil S.A., Aboalola A.A., Al-Ghalib T.A., Eshky R.T., Niyazi A.A., Mawardi M.H
Attisano (2001) Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways