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However, in the largest trial of plasma exchange for ALF, no significant difference was noted in intracranial pressure between the two groups, likely because of under-powering as only 16 patients had intracranial pressure measured, with no further details about improvement in HE [100]

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Compared with conventional formulations, NPs can provide more controlled drug release, and higher delivery precision, which may increase bioavailability and prolonged therapeutic exposure [19, 20]

Symptoms include shakiness, sweating, confusion, rapid heartbeat, and dizziness

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