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45,46 GLP-1RAs GLP-1RAs result from intricate structural modifications to GLP-1, enabling them to not only replicate the pharmacological functions of GLP-1 but also impede its hydrolysis by DPP-4, thereby extending the drugs half-life

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Weeks 1 to 4 The gut symptoms are usually at their worst while the dose climbs, then ease (Moiz 2025)

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NNMT inhibition via 5-Amino-1MQ was associated with higher NAD+ levels, thereby influencing sirtuin activation and mitochondrial function