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All other data supporting the findings of this study are available from the corresponding authors on reasonable request

IGF-1 LR3 contains a 13-amino-acid N-terminal extension and glutamic acid substitution at position 3, which reduces binding affinity to IGF-binding proteins (IGFBPs) by approximately 100-fold while maintaining full IGF-1 receptor binding capacity

BM-MSCs can be transplanted using different methods depending on the target tissues or organs, such as intravenous injection, local injection and scaffold-based transplantation

Whilst budget considerations are important, the cheapest option isn't always the best value

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