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reported a tirzepatide-associated large-bowel obstruction necessitating colectomy [13-15]

2024;103: e14454

Summary: Metformin and semaglutide work through complementary mechanismsmetformin reduces liver glucose production and improves insulin sensitivity, whilst semaglutide enhances insulin secretion, suppresses appetite, and slows gastric emptyingproviding superior blood sugar control and weight loss when used together

Probiotics could be part of a complementary therapy alongside GLP-1RA treatment to improve unwanted GI side effects and promote a diverse microbiome (See Table 1 for specific dosing protocols)

This could involve adding another medication to your treatment plan, such as insulin or a different type of diabetes medication