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Furthermore, in snapshots around 320450 ns, the upper half of helix I moves together with the ECD away from the orthosteric pocket of the TMD, providing enough space for binding of the GLP-1s C-terminus to the ECD as well as docking of the N-terminus of GLP-1 to the orthosteric pocket in the TMD

Side effects included gastrointestinal disorders (including nausea and vomiting), which affected 10% of people who used Wegovy compared to 2% of people who used the placebo

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Fat mass reduction The body composition substudy measured total fat mass changes using dual-energy X-ray absorptiometry, the gold standard for distinguishing fat from lean tissue

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