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Common early side effects like nausea and reduced appetite are usually mild to moderate and tend to diminish as your body adapts

Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

These sites increase the likelihood of patch displacement and may result in subtherapeutic drug levels

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