Ci thin sc khe no b: L-glutathione ng mt vai tr quan trng trong vic duy tr chc nng no ti u v sc khe nhn thc
falciparum standard in vitro culture conditions were conducted as previously described ( Eryptosis Assay and Flow Cytometry Analysis Previously described eryptosis inducers were selected for this study based on their use (or potential use) in the clinic, their known targets and/or their previously described antimalarial activity ( Table 1 ): amiodarone HCl (Selleck Chem, #S1979), apigenin (Selleck Chem, #S2262), BAY 43-9006 (AdipoGen Life Sciences, #AG-CR1-0025), benzethonium chloride (Selleck Chem, #S4162), cordycepin (Cayman Chemicals, #14426), ionomycin (ThermoFisher, #I24222) and oridonin (Selleck Chem, #S2335)
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The extraction and analysis processes followed the same protocol as described for the in vitro studies
This reaction is catalyzed by glutathione peroxidase (GPx), producing oxidized GSSG, which is subsequently recycled back to GSH by glutathione reductase
