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Such an effect results from different mechanisms, including the activation of muscarinic cholinergic receptors, and the increased expression of mGlu2 receptors in dorsal root ganglia neurons, by means of an acetylation mechanism involving transcription factors of the nuclear factor (NF)-kappaB family

Rational design and synthesis of novel dual PROTACs for simultaneous degradation of EGFR and PARP

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doi: 10.1038/nature09454 21 RabbieRFergusonPMolina-AguilarCAdamsDJRobles-EspinozaCD

While generally well-tolerated, ongoing studies aim to understand its long-term safety and efficacy better, positioning Melanotan I as a promising tool in photoprotection and dermatology