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Tirzepatide (going by the brand names Mounjaro and Zepbound) is the only dual agonist currently approved in Canada

Human and Clinical Evidence Current human research indicates that arginine produces inconsistent effects: modest improvements in vascular function and endurance in some studies, but little to no impact on hypertrophy or resistance performance in pooled analyses

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Cardiovasc Diabetol 17:153 Chilton R, Tikkanen I, Cannon CP et al (2015) Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes