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This decreased appetite naturally leads to a reduction in food intake, which is a critical factor in weight loss

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IGF-1 DES binds IGFBP-3 poorly, similar to LR3, but it also has roughly ten-fold higher potency at IGF-1R because the N-terminal tripeptide normally dampens receptor-binding affinity

In the SUSTAIN 7 study, semaglutide demonstrated greater effectiveness than other GLP-1 receptor agonists, showing marked reductions in both HbA1c and body weight compared to dulaglutide [8]