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Metformin demonstrates antioxidative effects through diverse molecular pathways, including SIRT3 and AMPK pathway activation, restoration of paraoxonase activity, and downregulation of NADPH oxidase expression

Human adult dermal fibroblasts incubated with GHK-Cu at concentrations of 0.01, 1, and 100 nM demonstrated increased production of both elastin and collagen, with all concentrations increasing TIMP1 expression and low concentrations enhancing MMP1 and MMP2 gene expression