May promote lean mass gains through sustained GH and IGF-1 elevation [2] [4]
The E-value associated with the stroke outcome, representing the minimal strength of association an unmeasured confounder must have with stroke in the follow-up and treatment selection to change the result of the study, is 2.07 (upper confidence interval: 1.58)
Since ferroptosis is an important process of cell death in various conditions, and GPX4 is its core regulator, further studies will be needed to understand how GPX4 is regulated in 3D spheroids, i.e., whether transcriptionally, post-transcriptionally, post-translationally or a combination of these regulatory mechanisms
The preference for metformin as the initial agent is based on its durable efficacy in lowering A1C, absence of risk for hypoglycemia or weight gain, relatively mild side-effect profile, longterm safety track record, and affordability
It also does not permit compounding of a drug that has never been approved by FDA for any use, because the active pharmaceutical ingredient(s) in such a product would not have been established as safe or effective
