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The article is structured so a reader can move from a baseline definition to mechanism, then to the trial data, then to a like-for-like comparison with tirzepatide and semaglutide, and finally to the regulatory and laboratory-handling questions that researchers most often ask

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C-kit is a transmembrane growth factor expressed in basal skin cells, melanocytes, epithelial cells of the breast, and mast cells, stimulation of which leads to activation (followed by the rapid degradation) of microphthalmia transcription factor (MITF)

2a,b) and an upwards movement of the side chain of phenylalanine F112 (Fig