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However, GPNA inhibits LAT1- and LAT2-mediated Gln uptake in a various human-derived cancer cells, and GPNA hydrolysis by the -glutamyltransferase enzyme generates the cytotoxic metabolite para-nitroaniline [55]

Sadri responded to FDA's Form 483 to explain the discrepancies, including delayed activation of the clinical trial site and shortening of the enrollment period, and said he would update the standard operating procedures

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New Engl J Med 2000;342:11717.PubMed 31