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This is often a sign of systemic "overdrive" as the liver and kidneys work to filter out the excess

Chronic heavy alcohol consumption can impair B12 status through poor dietary intake and malabsorption, though occasional alcohol is unlikely to significantly affect supplement absorption

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Glutathione is a powerful antioxidant that helps protect cells from damage, promotes detoxification, and supports immune function

The above leads to the overproduction of ROS and RNS, and it intensifies cytokine and chemokine secretion via a positive feedback loop (174)