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Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

Hennen S, Kodra JT, Soroka V, Krogh BO, Wu X, Kaastrup P, et al

A novel example of metabolic competition is found in CRC, where tumor cells deplete microenvironmental lysophosphatidic acid (LPA) resources via lysophosphatidic acid acyltransferase 4

However, it was decreased in response to metolachlor stress

In addition, there are multiple other drugs currently under development, including several oral drugs such as Orforglipron from Eli Lilly and Danuglipron from Pfizer, as well as further dual and triple receptor agonists