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De Leo E, Elmonem MA, Berlingerio SP, Berquez M, Festa BP, Raso R, Bellomo F, Starborg T, Janssen MJ, Abbaszadeh Z, Cairoli S, Goffredo BM, Masereeuw R, Devuyst O, Lowe M, Levtchenko E, Luciani A, Emma F, Rega LR (2020) Cell-based phenotypic drug screening identifies luteolin as candidate therapeutic for nephropathic cystinosis

Importantly, after three-month treatments of animals, the nanocarriers caused significantly lower gastric damage score than the free drug

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Additionally, the inhibition of GPX4 was thought to accelerate uncontrolled lipid peroxidation, leading to cell death, whereas GPX4 and ACSL4 double knockout cells had significantly prolonged overall survival (Yang et al., 2016)