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The 2024 Cureus systematic review by Jaiswal and Jawade reaches the same conclusions across more than 60 cited studies: the wound-healing cascade and the delivery enhancement are two separable mechanisms, and which one dominates depends on needle depth, needle architecture, and how the serum is introduced [1]

Growth-hormone secretagogues such as CJC-1295 and Ipamorelin raise GH and IGF-1 gradually through the pituitary, while steroids act directly on muscle tissue