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In decompensated cirrhosis, patients are symptomatic, due to significant fibrotic changes, and present with one or more of the following: ascites, jaundice, hepatic encephalopathy, or variceal hemorrhage.(2) Of note cirrhosis is one of five conditions encompassed by the broad category metabolic dysfunction-associated steatotic liver disease (MASLD).(3) Background: How GLP-1 RAs Work and Potential Cirrhosis Benefit GLP-1 RAs stimulate prandial insulin secretion, limiting glucagon production, slowing gastric motility and increasing satiety

2025 Apr 25;12:1566498

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Unlike earlier GHRPs, Ipamorelin has high selectivity, minimal effect on cortisol or prolactin, and is considered one of the cleanest GH-releasing peptides studied