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Specifically, increased expression of peroxisome proliferator-activated receptor- coactivator-1 protein, a key regulator of mitochondrial biosynthesis, disrupts the mitochondrial structure and leads to dysfunctional proliferation, which is involved in the development of certain cardiac diseases, such as heart failure and atherosclerosis (45)

Polyubiquitin was stained the FK1 antibody (Novus, NBP3-11039 lot MU188322) diluted 1:250 in PBS with BSA

To further define the pharmacological profile of PF-06882961, we sought to determine its binding affinity using radioligand binding assays

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